![]() Regular assessment of renal function is necessary (see section 4.4)Ī GFR should be assessed before initiation of treatment with metformin containing products and at least annually thereafter. Metformin hydrochloride is given at the usual starting dose of 500 mg or 850 mg 2 or 3 times daily, while insulin dosage is adjusted on the basis of blood glucose measurements.ĭue to potential for decreased renal function in elderly subjects, the metformin dosage should be adjusted based on renal function. Metformin and insulin may be used in combination therapy to achieve better blood glucose control. If transfer from another oral antidiabetic agent is intended, discontinue the other agent and initiate metformin at the dose indicated above. The maximum recommended dose of metformin hydrochloride is 3 g daily, taken as 3 divided doses. A slow increase of dose may improve gastrointestinal tolerability. After 10 to 15 days the dose should be adjusted on the basis of blood glucose measurements. The usual starting dose is 500 mg or 850 mg metformin hydrochloride 2 or 3 times daily given during or after meals. Monotherapy and combination with other oral antidiabetic agents Adults with normal renal function (GFR≥ 90 mL/min)
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